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One of them is the systemic anti-inflammatory effect, which is mediated as a consequence of the inhibitory effect on cytokine release due to their interference with the NF-kB signaling pathways [45]
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In fact, lower IRRs were observed during both the initial (0–12 months) and late (13–24 months) exposed periods compared with pretreatment, a pattern also seen for SGLT-2 and DPP-4 inhibitors, possibly reflecting increased healthcare contact or a healthier lifestyle during treatment
